Unique HIV type 1 V3 region sequences derived from six different regions of brain: region-specific evolution within host-determined quasispecies.

@article{Chang1998UniqueHT,
  title={Unique HIV type 1 V3 region sequences derived from six different regions of brain: region-specific evolution within host-determined quasispecies.},
  author={John Chang and Radoslaw Jozwiak and Bin Wang and Teresa I. Ng and Y. C. Ge and Wayne V Bolton and Dominic Edmund Dwyer and Chester Randle and Ruby Osborn and Anthony L Cunningham and Nitin K Saksena},
  journal={AIDS research and human retroviruses},
  year={1998},
  volume={14 1},
  pages={25-30}
}
HIV type 1 viral quasispecies were amplified by polymerase chain reaction (PCR) in the hypervariable V3 region of gp120 from six different regions of the brain (right and left frontal; right and left parietal; and right and left occipital) and from the peripheral blood mononuclear cells (PBMCs) of a patient who died of AIDS dementia complex (ADC). Cloning and sequencing of the entire V3 region suggested the presence of genetically unique sequences in different regions of the brain. In contrast… CONTINUE READING

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