Unique Features of a Pseudomonas aeruginosa α2-Macroglobulin Homolog

@inproceedings{RobertGenthon2013UniqueFO,
  title={Unique Features of a Pseudomonas aeruginosa α2-Macroglobulin Homolog},
  author={Myl{\`e}ne Robert-Genthon and Maria Guillermina Casabona and David Emilio Santos Neves and Yohann Cout{\'e} and F{\'e}lix Cic{\'e}ron and Sylvie Elsen and Andr{\'e}a Dessen and Ina Attr{\'e}e},
  booktitle={mBio},
  year={2013}
}
UNLABELLED Human pathogens frequently use protein mimicry to manipulate host cells in order to promote their survival. Here we show that the opportunistic pathogen Pseudomonas aeruginosa synthesizes a structural homolog of the human α2-macroglobulin, a large-spectrum protease inhibitor and important player of innate immunity. Small-angle X-ray scattering analysis demonstrated that the fold of P. aeruginosa MagD (PA4489) is similar to that of the human macroglobulin and undergoes a… CONTINUE READING

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