Unique Features of a Pseudomonas aeruginosa α2-Macroglobulin Homolog

  title={Unique Features of a Pseudomonas aeruginosa α2-Macroglobulin Homolog},
  author={Myl{\`e}ne Robert-Genthon and Maria Guillermina Casabona and David Emilio Santos Neves and Yohann Cout{\'e} and F{\'e}lix Cic{\'e}ron and Sylvie Elsen and Andr{\'e}a Dessen and Ina Attr{\'e}e},
UNLABELLED Human pathogens frequently use protein mimicry to manipulate host cells in order to promote their survival. Here we show that the opportunistic pathogen Pseudomonas aeruginosa synthesizes a structural homolog of the human α2-macroglobulin, a large-spectrum protease inhibitor and important player of innate immunity. Small-angle X-ray scattering analysis demonstrated that the fold of P. aeruginosa MagD (PA4489) is similar to that of the human macroglobulin and undergoes a… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 55 references

Multiple sensors control reciprocal expression of Pseudomonas aeruginosa regulatory RNA and virulence genes.

Proceedings of the National Academy of Sciences of the United States of America • 2006
View 4 Excerpts
Highly Influenced

Heat-induced fragmentation of human alpha 2-macroglobulin.

The Journal of biological chemistry • 1979
View 13 Excerpts
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