Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.

  title={Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.},
  author={Sadia Mohsin and Constantine D. Troupes and Timothy Starosta and Thomas E. Sharp and Elorm J. Agra and Shavonn C. Smith and Jason M. Duran and Neil Zalavadia and Yan Zhou and Hajime Kubo and Remus M. Berretta and Steven R. Houser},
  journal={Circulation research},
  volume={117 12},
RATIONALE Adoptive transfer of multiple stem cell types has only had modest effects on the structure and function of failing human hearts. Despite increasing the use of stem cell therapies, consensus on the optimal stem cell type is not adequately defined. The modest cardiac repair and functional improvement in patients with cardiac disease warrants identification of a novel stem cell population that possesses properties that induce a more substantial improvement in patients with heart failure… 

Figures from this paper

Bmi1 Augments Proliferation and Survival of Cortical Bone-Derived Stem Cells after Injury through Novel Epigenetic Signaling via Histone 3 Regulation

In the absence of Bmi1, CBSCs lose their proliferative potential, have increased DNA damage and apoptosis, and more cell cycle arrest due to changes in epigenetic modifications.

Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction

CBSC administration into the MI border zone reduces pathological cardiac structural and functional remodeling and improves left ventricular functional reserve and reduce those processes that can lead to heart failure with reduced ejection fraction.

Cell Surface and Functional Features of Cortical Bone Stem Cells

It is found that mouse cortical-bone-derived stem cells secrete a greater amount of TGF-β1 compared to mMSCs, and that the TGF -β1 contributed to the self-migration of mCBSCs and activation of fibroblasts.

Cortical Bone Derived Stem Cells Modulate Cardiac Fibroblast Response via miR-18a in the Heart After Injury

CBSCs reduce fibroblast to myofibroblast transition and differentiation in adult cardiac fibroblasts via miR-18a-5p and provides a resolution for the cardiac repair response after injury in the adult myocardium.

Mammalian MSC from selected species: Features and applications

It is mandatory to unravel the response of MSC from a given source onto a specific disease environment in suitable animal models prior to clinical applications.

Follistatin-like 1 protects mesenchymal stem cells from hypoxic damage and enhances their therapeutic efficacy in a mouse myocardial infarction model

In vitro study demonstrated that Fstl1 promotes survival and proliferation of hypoxic MSCs, thereby optimizing their engraftment and therapeutic efficacy during cell therapy and transplantation with FSTl1-overexpressing M SCs significantly improves post-MI cardiac function.

“Empowering” Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter?

An overview on aging effects of stem cells and mitochondria which might be important for mitochondrial transplantation is provided and an overview on the current state in this field is given together with considerations worthwhile for further investigations.

C1q/Tumor Necrosis Factor–Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways

Evidence is provided that CTRP9 is a cardiokine critical in maintaining a healthy microenvironment facilitating stem cell engraftment in infarcted myocardial tissue, thereby enhancing stem cell therapeutic efficacy and attenuating cardiomyocyte cell death by previously unrecognized signaling mechanisms.

Resistin promotes cardiac homing of mesenchymal stem cells and functional recovery after myocardial ischemia-reperfusion via the ERK1/2-MMP-9 pathway.

  • Yuan HeYanjie Guo L. Tao
  • Biology, Medicine
    American journal of physiology. Heart and circulatory physiology
  • 2019
It is demonstrated that resistin can promote homing of injected ADSCs into damaged heart tissue and stimulate functional recovery, an effect mediated through the ERK1/2 signaling pathway and matrix metalloproteinase-9.

Tailorable Hydrogel Improves Retention and Cardioprotection of Intramyocardial Transplanted Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice

The Col‐Tgel creates a suitable microenvironment for long‐term retention of ADSCs in an ischemic area, and thereby enhances their cardioprotective effects, and may provide an alternative biomaterial for stem cell‐based therapy to treat isChemic heart diseases.



Challenges in identifying the best source of stem cells for cardiac regeneration therapy

An overview of different types of stem cells currently being considered for cardiac regeneration are provided and why associated factors such as practicality and difficulty in cell collection should also be considered when selecting the stem cells for transplantation are discussed.

Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms

CBSC therapy improved survival, cardiac function, regional strain, attenuated remodeling, and decreased infarct size relative to cardiac-derived stem cells– or saline-treated myocardial infarction controls through the following 2 mechanisms: secretion of proangiogenic factors that stimulate endogenous neovascularization, and differentiation into functional adult myocytes and vascular cells.

Increased Potency of Cardiac Stem Cells Compared with Bone Marrow Mesenchymal Stem Cells in Cardiac Repair

A greater potency of CSCs than bone marrow MSCs in cardiac repair is demonstrated and enhanced CSC engraftment, differentiation, and improved cardiac remodeling and function in ischemic heart failure is demonstrated.

Isolation and Expansion of Adult Cardiac Stem Cells From Human and Murine Heart

The isolation of undifferentiated cells that grow as self-adherent clusters (that are termed “cardiospheres”) from subcultures of postnatal atrial or ventricular human biopsy specimens and from murine hearts are described.

Preservation of Myocardial Structure Is Enhanced by Pim-1 Engineering of Bone Marrow Cells

Genetic modification of BMCs with Pim-1 may serve as a therapeutic approach to promote recovery of myocardial structure and take advantage of salutary BMC actions in conjunction with other stem cell types to increase efficacy of cellular therapy and improve myocardIAL performance in the injured myocardium.

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.

Empowering adult stem cells for myocardial regeneration.

Biological properties of approached to potentiate stem cell-mediated regeneration to promote enhanced myocardial regeneration, persistence of donated cells, and long-lasting tissue repair are highlighted.

Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair.

Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction.

It is demonstrated that mouse ESC-derived exosomes (mES Ex) possess ability to augment function in infarcted hearts and provide a novel cell-free system that uses the immense regenerative power of ES cells while avoiding the risks associated with direct ES or ES-derived cell transplantation and risk of teratomas.