Unique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma.

@article{Lleras2013UniqueDM,
  title={Unique DNA methylation loci distinguish anatomic site and HPV status in head and neck squamous cell carcinoma.},
  author={Roberto A Lleras and Richard V Smith and Leslie R Adrien and Nicolas F. Schlecht and Robert D Burk and Thomas M. Harris and Geoffrey J Childs and Michael B. Prystowsky and Thomas J. Belbin},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 19},
  pages={5444-55}
}
PURPOSE We have used a genome-wide approach to identify novel differentially methylated CpG dinucleotides that are seen in different anatomic sites of head and neck squamous cell carcinoma (HNSCC), as well as those that might be related to HPV status in the oropharynx. EXPERIMENTAL DESIGN We conducted genome-wide DNA methylation profiling of primary tumor samples and corresponding adjacent mucosa from 118 HNSCC patients undergoing treatment at Montefiore Medical Center, Bronx, NY, using the… CONTINUE READING