Unique Aspects of the Developing Lung Circulation: Structural Development and Regulation of Vasomotor Tone

@article{Gao2016UniqueAO,
  title={Unique Aspects of the Developing Lung Circulation: Structural Development and Regulation of Vasomotor Tone},
  author={Yuangsheng Gao and David N. Cornfield and Kurt R Stenmark and Bernard Th{\'e}baud and Steven H Abman and J. Usha Raj},
  journal={Pulmonary Circulation},
  year={2016},
  volume={6},
  pages={407 - 425}
}
This review summarizes our current knowledge on lung vasculogenesis and angiogenesis during normal lung development and the regulation of fetal and postnatal pulmonary vascular tone. In comparison to that of the adult, the pulmonary circulation of the fetus and newborn displays many unique characteristics. Moreover, altered development of pulmonary vasculature plays a more prominent role in compromised pulmonary vasoreactivity than in the adult. Clinically, a better understanding of the… CONTINUE READING