Unintegrated HTLV-I proviral DNA in cell lines and uncultured peripheral blood mononuclear cells from tropical spastic paraparesis (TSP/HAM) and adult T-cell leukemia (ATL) patients.

@article{Bazarbachi1994UnintegratedHP,
  title={Unintegrated HTLV-I proviral DNA in cell lines and uncultured peripheral blood mononuclear cells from tropical spastic paraparesis (TSP/HAM) and adult T-cell leukemia (ATL) patients.},
  author={Ali Bazarbachi and Frederick A. Saal and J. Lasneret and Y Poirot and Patricia Bittoun and Frida Hojman and Jorge Peries},
  journal={Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie},
  year={1994},
  volume={317 3},
  pages={264-9}
}
Ultrastructural studies on cell cultures derived from TSP/HAM and ATL patients, show the presence of large quantities of HTLV-I viral particles in extracellular spaces and budding at the cytoplasmic membrane. In addition, mature enveloped particles and images of endopinocytosis of virions are seen in the cytoplasm vacuoles suggesting the existence of a… CONTINUE READING