Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey.

@article{Ali1999UninjuredCN,
  title={Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey.},
  author={Zahid Ali and Matthias Ringkamp and Timothy V Hartke and H. F. Chien and Nicholas A Flavahan and J. N. Campbell and Richard A. Meyer},
  journal={Journal of neurophysiology},
  year={1999},
  volume={81 2},
  pages={
          455-66
        }
}
We investigated whether uninjured cutaneous C-fiber nociceptors in primates develop abnormal responses after partial denervation of the skin. Partial denervation was induced by tightly ligating spinal nerve L6 that innervates the dorsum of the foot. Using an in vitro skin-nerve preparation, we recorded from uninjured single afferent nerve fibers in the superficial peroneal nerve. Recordings were made from 32 C-fiber nociceptors 2-3 wk after ligation and from 29 C-fiber nociceptors in control… 

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