Unimpaired immune functions in the absence of Mrp4 (Abcc4).

@article{Ven2009UnimpairedIF,
  title={Unimpaired immune functions in the absence of Mrp4 (Abcc4).},
  author={Rieneke van de Ven and Jan Willem B. de Groot and Anneke W. Reurs and Pepijn G.J.T.B. Wijnands and Koen van de Wetering and John D. Schuetz and Tanja D. de Gruijl and Rik J. Scheper and George L. Scheffer},
  journal={Immunology letters},
  year={2009},
  volume={124 2},
  pages={
          81-7
        }
}
Dendritic cell (DC) migration to draining lymph nodes is important for the initiation of an effective immune response. Recently we reported that the human ATP-binding cassette (ABC) transporter multidrug resistance protein 4 (MRP4 and ABCC4) is required for the migration of human DC. Since the ABC transporter MRP1 (ABCC1) was previously shown to play a role in both human and mouse DC migration, we here studied whether Mrp4 is similarly required for DC migration in mice and whether the absence… CONTINUE READING

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