Unimpaired Skin Carcinogenesis in Desmoglein 3 Knockout Mice

  title={Unimpaired Skin Carcinogenesis in Desmoglein 3 Knockout Mice},
  author={Sylvain Baron and Anabel Hoang and Hannes Vogel and Laura Attardi},
  booktitle={PloS one},
The contribution of adherens junction inactivation, typically by downregulation or mutation of the transmembrane core component E-cadherin, to cancer progression is well recognized. In contrast, the role of the desmosomal cadherin components of the related cell-cell adhesion junction, the desmosome, in cancer development has not been well explored. Here, we use mouse models to probe the functional role of desmosomal cadherins in carcinogenesis. Because mice lacking the desmosomal cadherin… CONTINUE READING

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