Unilateral subthalamotomy in the treatment of Parkinson's disease.

  title={Unilateral subthalamotomy in the treatment of Parkinson's disease.},
  author={Nikunj K. Patel and Peter Heywood and Karen L O'Sullivan and Renee L McCarter and Seth Love and Steven S Gill},
  journal={Brain : a journal of neurology},
  volume={126 Pt 5},
Hyperactivity in the subthalamic nucleus (STN) is seen in animal models of Parkinson's disease, and lesioning of the STN dramatically relieves the animal's parkinsonism. Deep brain stimulation (DBS) of the STN is an effective treatment for patients with advanced Parkinson's disease. We have studied the effects of a unilateral lesion placed in the STN in predominantly hemi-parkinsonian patients. Twenty-one patients with advanced idiopathic Parkinson's disease were studied. Seventeen had… CONTINUE READING