Unilateral cortical spreading depression affects sleep need and induces molecular and electrophysiological signs of synaptic potentiation in vivo.

@article{Faraguna2010UnilateralCS,
  title={Unilateral cortical spreading depression affects sleep need and induces molecular and electrophysiological signs of synaptic potentiation in vivo.},
  author={Ugo Faraguna and Aaron B. Nelson and Vladyslav V Vyazovskiy and Chiara Cirelli and Giulio Tononi},
  journal={Cerebral cortex},
  year={2010},
  volume={20 12},
  pages={
          2939-47
        }
}
Cortical spreading depression (CSD) is an electrophysiological phenomenon first described by Leao in 1944 as a suppression of spontaneous electroencephalographic activity, traveling across the cerebral cortex. In vitro studies suggest that CSD may induce synaptic potentiation. One recent study also found that CSD is followed by a non-rapid eye movement (NREM) sleep duration increase, suggesting an increased need for sleep. Recent experiments in animals and humans show that the occurrence of… CONTINUE READING

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