Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats.

@article{Radhakrishnan2003UnilateralCI,
  title={Unilateral carrageenan injection into muscle or joint induces chronic bilateral hyperalgesia in rats.},
  author={Rajan Radhakrishnan and Steven A. Moore and Kathleen A Sluka},
  journal={Pain},
  year={2003},
  volume={104 3},
  pages={567-77}
}
Chronic musculoskeletal pain is a major clinical problem and there is a general lack of animal models to study this condition. Carrageenan is commonly used to produce short-lasting acute inflammation and hyperalgesia in animal models. However, the potential of carrageenan to produce chronic, long-lasting hyperalgesia has not been evaluated. In the present study, we investigated the long-term effects of carrageenan injected into joint or muscle in rats. Rats were injected with 0.3, 1 or 3… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS

From This Paper

Topics from this paper.
70 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 70 extracted citations

Similar Papers

Loading similar papers…