Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen.

@article{Romero2000Unilateral6L,
  title={Unilateral 6-hydroxydopamine lesions of nigrostriatal dopaminergic neurons increased CB1 receptor mRNA levels in the caudate-putamen.},
  author={J Barjau Romero and Fernando Berrendero and Alberto P{\'e}rez-Rosado and Jorge Manzanares and Ana Lara Rojo and Javier J. Fernandez-Ruiz and Justo Garc{\'i}a de Y{\'e}benes and Jos{\'e} Antonio Vera Ramos},
  journal={Life sciences},
  year={2000},
  volume={66 6},
  pages={485-94}
}
It has been recently suggested that the effects of cannabinoids on motor behavior might be different in rats with lesions of nigrostriatal dopaminergic neurons than in controls. In the present study, we examined the possible alteration in the status of cannabinoid CB1 receptors in the basal ganglia of rats with unilateral lesions of those neurons caused by 6-hydroxydopamine. We used two different experimental groups depending on the duration of the period of recovery after the lesion, and… CONTINUE READING

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