Unilateral 6-hydroxydopamine Lesions of Meso-striatal Dopamine Neurons and Their Physiological Sequelae

@article{Schwarting1996Unilateral6L,
  title={Unilateral 6-hydroxydopamine Lesions of Meso-striatal Dopamine Neurons and Their Physiological Sequelae},
  author={Rainer K W Schwarting and Joseph P. Huston},
  journal={Progress in Neurobiology},
  year={1996},
  volume={49},
  pages={215-266}
}
One of the primary approaches in experimental brain research is to investigate the effects of specific destruction of its parts. Here, several neurotoxins are available which can be used to eliminate neurons of a certain neurochemical type or family. With respect to the study of dopamine neurons in the brain, especially within the basal ganglia, the neurotoxin 6-hydroxydopamine (6-OHDA) provides an important tool. The most common version of lesion induced with this toxin is the unilateral… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 124 extracted citations

Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2008
View 5 Excerpts
Highly Influenced

Effects of pcDNA3-β-NGF Gene-modified BMSC on the Rat Model of Parkinson’s Disease

Journal of Molecular Neuroscience • 2007
View 6 Excerpts
Highly Influenced

A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2017
View 2 Excerpts
Highly Influenced

Prototypic and arkypallidal neurons in the dopamine-intact external globus pallidus.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2015
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…