Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus.

  title={Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus.},
  author={Leslie A. Real and Jon C. Henderson and Roman Biek and Jennifer M Snaman and Tracy Lambert Jack and James Emory Childs and Eli Ea Stahl and L. Rusty Waller and Rowland R. Tinline and Susan Nadin-Davis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 34},
Infectious disease emergence is under the simultaneous influence of both genetic and ecological factors. Yet, we lack a general framework for linking ecological dynamics of infectious disease with underlying molecular and evolutionary change. As a model, we illustrate the linkage between ecological and evolutionary dynamics in rabies virus during its epidemic expansion into eastern and southern Ontario. We characterized the phylogeographic relationships among 83 isolates of fox rabies virus… CONTINUE READING
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