Unifying the Epidemiological and Evolutionary Dynamics of Pathogens

@article{Grenfell2004UnifyingTE,
  title={Unifying the Epidemiological and Evolutionary Dynamics of Pathogens},
  author={Bryan T. Grenfell and Oliver G. Pybus and Julia R. Gog and James L. N. Wood and Janet M. Daly and Jenny A. Mumford and Edward C. Holmes},
  journal={Science},
  year={2004},
  volume={303},
  pages={327 - 332}
}
A key priority for infectious disease research is to clarify how pathogen genetic variation, modulated by host immunity, transmission bottlenecks, and epidemic dynamics, determines the wide variety of pathogen phylogenies observed at scales that range from individual host to population. We call the melding of immunodynamics, epidemiology, and evolutionary biology required to achieve this synthesis pathogen “phylodynamics.” We introduce a phylodynamic framework for the dissection of dynamic… 

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