Unifying roles for regulatory T cells and inflammation in cancer.

@article{Erdman2010UnifyingRF,
  title={Unifying roles for regulatory T cells and inflammation in cancer.},
  author={Susan E. Erdman and Varada P. Rao and Werner Olipitz and Christie L Taylor and Erin A. Jackson and Tatiana Levkovich and Chung-Wei Lee and Bruce H Horwitz and James G Fox and Zhongming Ge and T Poutahidis},
  journal={International journal of cancer},
  year={2010},
  volume={126 7},
  pages={1651-65}
}
Activities of CD4(+) regulatory (T(REG)) cells restore immune homeostasis during chronic inflammatory disorders. Roles for T(REG) cells in inflammation-associated cancers, however, are paradoxical. It is widely believed that T(REG) function in cancer mainly to suppress protective anticancer responses. However, we demonstrate here that T(REG) cells also function to reduce cancer risk throughout the body by efficiently downregulating inflammation arising from the gastrointestinal (GI) tract… CONTINUE READING
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