Unifying features in protein-folding mechanisms.

  title={Unifying features in protein-folding mechanisms.},
  author={Stefano Gianni and Nicholas R. Guydosh and Faaizah Khan and Teresa D Caldas and Ugo Mayor and George W N White and Mari L Demarco and Valerie Daggett and A. R. Fersht},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 23},
We compare the folding of representative members of a protein superfamily by experiment and simulation to investigate common features in folding mechanisms. The homeodomain superfamily of three-helical, single-domain proteins exhibits a spectrum of folding processes that spans the complete transition from concurrent secondary and tertiary structure formation (nucleation-condensation mechanism) to sequential secondary and tertiary formation (framework mechanism). The unifying factor in their… CONTINUE READING

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