Unifying aging and frailty through complex dynamical networks.

  title={Unifying aging and frailty through complex dynamical networks.},
  author={Andrew D. Rutenberg and Arnold Mitnitski and Spencer G. Farrell and Kenneth Rockwood},
  journal={Experimental gerontology},
To explore the mechanistic relationships between aging, frailty and mortality, we developed a computational model in which possible health attributes are represented by the nodes of a complex network, with the connections showing a scale-free distribution. Each node can be either damaged (i.e. a deficit) or undamaged. Damage of connected nodes facilitates local damage and makes local recovery more difficult. Our model demonstrates the known patterns of frailty and mortality without any… CONTINUE READING
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