Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity.

@article{Schoonen2007UniformPO,
  title={Uniform procedure of (1)H NMR analysis of rat urine and toxicometabonomics Part II: comparison of NMR profiles for classification of hepatotoxicity.},
  author={Willem G. E. J. Schoonen and Cathelijne P A M Kloks and J H Ploemen and Martin J. Smit and Pieter Zandberg and G J M J Horbach and Jan-Remt Mellema and Carol Thijssen-Vanzuylen and A. Cuneyt Tas and Joop H J van Nesselrooij and Jack T. W. E. Vogels},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2007},
  volume={98 1},
  pages={286-97}
}
A procedure of nuclear magnetic resonance (NMR) urinalysis using pattern recognition is proposed for early detection of toxicity of investigational compounds in rats. The method is applied to detect toxicity upon administration of 13 toxic reference compounds and one nontoxic control compound (mianserine) in rats. The toxic compounds are expected to induce necrosis (bromobenzene, paracetamol, carbon tetrachloride, iproniazid, isoniazid, thioacetamide), cholestasis (alpha-naphthylisothiocyanate… CONTINUE READING