Uniform binding of aminoacylated transfer RNAs to the ribosomal A and P sites.

@article{Fahlman2004UniformBO,
  title={Uniform binding of aminoacylated transfer RNAs to the ribosomal A and P sites.},
  author={Richard Peter Fahlman and Taraka Dale and O. C. Uhlenbeck},
  journal={Molecular cell},
  year={2004},
  volume={16 5},
  pages={799-805}
}
The association and dissociation rate constants of eight different E. coli aminoacyl-tRNAs (aa-tRNAs) for E. coli ribosomes programmed with mRNAs of defined sequences were determined. Identical association and dissociation rate constants were observed for all eight aa-tRNAs in both the ribosomal A and P sites despite substantial differences in tRNA sequence, the type of esterified amino acid, and posttranscriptional modifications. These results indicate that the overall binding of all aa-tRNAs… CONTINUE READING

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