Unified model for the corneal permeability of related and diverse compounds with respect to their physicochemical properties.

@article{Yoshida1996UnifiedMF,
  title={Unified model for the corneal permeability of related and diverse compounds with respect to their physicochemical properties.},
  author={Fusayo Yoshida and John G. Topliss},
  journal={Journal of pharmaceutical sciences},
  year={1996},
  volume={85 8},
  pages={
          819-23
        }
}
Corneal permeability data taken from the literature were analyzed for possible quantitative relationships with physicochemical properties. Although a parabolic relationship was obtained with good correlation between lipophilicity, as expressed by the 1-octanol-water partition coefficients, log Poctanol (or the distribution coefficients, log D for ionizable compounds), and the permeability in individual analyses of compound classes such as beta-adrenoceptor blockers and steroids, the correlation… CONTINUE READING
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