Unified Approach toward Syntheses of Juglomycins and Their Derivatives

  title={Unified Approach toward Syntheses of Juglomycins and Their Derivatives},
  author={Kai Yoshioka and Shogo Kamo and Keisuke Hosaka and Ryohei Sato and Yuma Miikeda and Yuri Manabe and Shusuke Tomoshige and Kazunori Tsubaki and Kouji Kuramochi},
  journal={ACS Omega},
  pages={11737 - 11748}
A unified and common intermediate strategy for syntheses of juglomycins and their derivatives is reported. The use of a 1,4-dimethoxynaphthalene derivative as a key intermediate enabled easy access to various juglomycin derivatives. In this study, juglomycins A–D, juglomycin C amide, khatmiamycin and its 4-epimer, and the structure proposed for juglomycin Z were synthesized from this intermediate. The absolute configuration of natural khatmiamycin has been established to be 3R,4R through our… 
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