Unified Analysis of Secondary Traits in Case-Control Association Studies.

  title={Unified Analysis of Secondary Traits in Case-Control Association Studies.},
  author={Arpita Ghosh and Fred A. Wright and Fei Zou},
  journal={Journal of the American Statistical Association},
  volume={108 502}
It has been repeatedly shown that in case-control association studies, analysis of a secondary trait which ignores the original sampling scheme can produce highly biased risk estimates. Although a number of approaches have been proposed to properly analyze secondary traits, most approaches fail to reproduce the marginal logistic model assumed for the original case-control trait and/or do not allow for interaction between secondary trait and genotype marker on primary disease risk. In addition… CONTINUE READING

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