Unfolding the role of protein misfolding in neurodegenerative diseases

@article{Soto2003UnfoldingTR,
  title={Unfolding the role of protein misfolding in neurodegenerative diseases},
  author={C. Soto},
  journal={Nature Reviews Neuroscience},
  year={2003},
  volume={4},
  pages={49-60}
}
  • C. Soto
  • Published 2003
  • Medicine, Biology
  • Nature Reviews Neuroscience
Recent evidence indicates that diverse neurodegenerative diseases might have a common cause and pathological mechanism — the misfolding, aggregation and accumulation of proteins in the brain, resulting in neuronal apoptosis. Studies from different disciplines strongly support this hypothesis and indicate that a common therapy for these devastating disorders might be possible. The aim of this article is to review the literature on the molecular mechanism of protein misfolding and aggregation… Expand
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