Unfolding free energy of a two-domain transmembrane sugar transport protein.

@article{Findlay2010UnfoldingFE,
  title={Unfolding free energy of a two-domain transmembrane sugar transport protein.},
  author={Heather E. Findlay and Nicholas G. Rutherford and Peter J F Henderson and Paula Booth},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 43},
  pages={18451-6}
}
Understanding how an amino acid sequence folds into a functional, three-dimensional structure has proved to be a formidable challenge in biological research, especially for transmembrane proteins with multiple alpha helical domains. Mechanistic folding studies on helical membrane proteins have been limited to unusually stable, single domain proteins such as bacteriorhodopsin. Here, we extend such work to flexible, multidomain proteins and one of the most widespread membrane transporter families… CONTINUE READING