Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.

@article{Sugiura2013UnfoldedPR,
  title={Unfolded protein response in keratinocytes: impact on normal and abnormal keratinization.},
  author={Kazumitsu Sugiura},
  journal={Journal of dermatological science},
  year={2013},
  volume={69 3},
  pages={181-6}
}
The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from stress caused by misfolded or unfolded proteins. As such, ER stress is an ongoing challenge for all cells, given the central biologic importance of secretion as part of normal physiologic functions. Mild UPR is activated by mild ER stress, which occurs under normal conditions. Abnormal UPR is activated by severe ER stress, which occurs under pathological… CONTINUE READING

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