Unfolded p53: a potential biomarker for Alzheimer's disease.

@article{Lanni2007UnfoldedPA,
  title={Unfolded p53: a potential biomarker for Alzheimer's disease.},
  author={Cristina Lanni and Daniela Letizia Uberti and Marco Racchi and Stefano M. Govoni and Maurizio Memo},
  journal={Journal of Alzheimer's disease : JAD},
  year={2007},
  volume={12 1},
  pages={
          93-9
        }
}
The identification of biological markers of AD can improve diagnostic accuracy and therapy follow-up as well as provide information on the pathogenesis of the disease. We recently found that fibroblasts derived from AD patients expressed an altered conformational status of p53 and were less sensitive to p53-dependent apoptosis compared to fibroblasts from non-AD subjects. When investigating the mechanism of such alteration, we found that the exposure to nanomolar concentrations of amyloid-beta… CONTINUE READING
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