Unexpectedly strong binding of a large metal ion (Bi3+) to human serum transferrin.

@article{Li1996UnexpectedlySB,
  title={Unexpectedly strong binding of a large metal ion (Bi3+) to human serum transferrin.},
  author={Hang Li and Peter J Sadler and Hongzhe Sun},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 16},
  pages={9483-9}
}
Large metal ions (>0.9 A ionic radius) have previously been found to bind only weakly to human serum transferrin (hTF, 80 kDa), presumably because the interdomain cleft cannot close around the metal and synergistic anion. Surprisingly, therefore, we report that Bi3+ (ionic radius 1.03 A), a metal ion widely used in anti-ulcer drugs, binds strongly to both the N- and C-lobes with log K1* = 19.42 and log K2* = 18.58 (10 mM Hepes, 5 mM bicarbonate, 310 K). The uptake of Bi3+ by apo-hTF from… CONTINUE READING

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