Unexpected thrombocytopenia and anemia in cynomolgus monkeys induced by a therapeutic human monoclonal antibody.

@article{Everds2013UnexpectedTA,
  title={Unexpected thrombocytopenia and anemia in cynomolgus monkeys induced by a therapeutic human monoclonal antibody.},
  author={Nancy E. Everds and Nianyu Li and Keith M. Bailey and Madeline Fort and Riki Stevenson and Remi Jawando and Kevin Salyers and Vibha Jawa and Padma Kumar Narayanan and Erin N Stevens and Ching He and Mai Thi Phuong Nguyen and Sam T Tran and Nancy S. Doyle and Florence M Poitout-Belissent and Jacquelin Jolette and Cen Xu and Katherine Sprugel},
  journal={Toxicologic pathology},
  year={2013},
  volume={41 7},
  pages={
          951-69
        }
}
Cynomolgus monkeys dosed with a therapeutic monoclonal antibody (mAbY.1) at ≥ 50 mg/kg had unexpected acute thrombocytopenia (nadir ~3,000 platelets/µl), sometimes with decreases in red cell mass. Increased activated macrophages, mitotic figures, and erythrophagocytosis were observed in the spleen. Binding of mAbY.1 to cynomolgus peripheral blood cells could not be detected in vitro. mAbY.1 induced phagocytosis of platelets by peripheral blood monocytes from cynomolgus monkeys, but not from… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

Repeated TLR9 stimulation results in macrophage activation syndrome-like disease in mice.

  • The Journal of clinical investigation
  • 2011
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin.

  • Toxicological sciences : an official journal of the Society of Toxicology
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Hemophagocytosis causes a consumptive anemia of inflammation

  • The Journal of experimental medicine
  • 2011
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Investigation of the mechanisms underlying rat-specific anti-EGFL-7-induced toxicities

J. A. Couch, B. Martin, +14 authors D. Danilenko
  • Poster presentation at the Annual Meeting of the Society of Toxicologic Pathology,
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

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