Unexpected synergy between N-phosphonacetyl-L-aspartate and cytidine against human tumor cells.

@article{Chan1989UnexpectedSB,
  title={Unexpected synergy between N-phosphonacetyl-L-aspartate and cytidine against human tumor cells.},
  author={T. Chan and S. Howell},
  journal={European journal of cancer & clinical oncology},
  year={1989},
  volume={25 4},
  pages={
          721-7
        }
}
  • T. Chan, S. Howell
  • Published 1989
  • Biology, Medicine
  • European journal of cancer & clinical oncology
Cytidine, a non-toxic endogenous nucleoside, was found unexpectedly to augment the cytotoxicity of a pyrimidine antimetabolite N-phosphonacetyl-L-aspartate (PALA) in human ovarian carcinoma cells. The PALA/cytidine synergy is confirmed here in other human tumor cells (T242 melanoma, HL60 promyelocytic leukemia and SKOV3 ovarian carcinoma) in the cytidine concentration range of 1-10 micromolar. The synergy was not observed in Chinese hamster ovary (CHO) cells. Exogenous uridine (5-50 microM… Expand
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References

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