Unexpected structural complexity of supernumerary marker chromosomes characterized by microarray comparative genomic hybridization

@article{Tsuchiya2008UnexpectedSC,
  title={Unexpected structural complexity of supernumerary marker chromosomes characterized by microarray comparative genomic hybridization},
  author={Karen Tsuchiya and Kent E Opheim and Mark C. Hannibal and Anne V. Hing and Ian A Glass and Michael L Raff and Thomas H. Norwood and Beth S. Torchia},
  journal={Molecular Cytogenetics},
  year={2008},
  volume={1},
  pages={7 - 7}
}
Supernumerary marker chromosomes (SMCs) are structurally abnormal extra chromosomes that cannot be unambiguously identified by conventional banding techniques. In the past, SMCs have been characterized using a variety of different molecular cytogenetic techniques. Although these techniques can sometimes identify the chromosome of origin of SMCs, they are cumbersome to perform and are not available in many clinical cytogenetic laboratories. Furthermore, they cannot precisely determine the region… CONTINUE READING

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The Metabolic and Molecular Bases of Inherited Disease Volume IV

  • M Muenke, Beachy PA Holoprosencephaly
  • 2008
2 Excerpts

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