Unexpected similarity of the structures of the weakly toxic amanitin (S)-sulfoxide and the highly toxic (R)-sulfoxide and sulfone as revealed by proton nuclear magnetic resonance and X-ray analysis.

Abstract

The three-dimensional structures of the slightly toxic diastereomeric (S)-sulfoxide of 6'-O-methyl-alpha-amanitin [6'-O-Me-alpha-ama (S)-sulfoxide, 4] and of the corresponding highly toxic sulfone 5 have been determined by X-ray diffraction analysis. The same derivatives along with 6'-O-methyl-alpha-amanitin [O-Me-alpha-ama (R)-sulfoxide, 3] and the… (More)

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Cite this paper

@article{Wieland1983UnexpectedSO, title={Unexpected similarity of the structures of the weakly toxic amanitin (S)-sulfoxide and the highly toxic (R)-sulfoxide and sulfone as revealed by proton nuclear magnetic resonance and X-ray analysis.}, author={Thomas Wieland and C G{\"o}tzend{\"o}rfer and Janusz M Dąbrowski and Wanda Lipscomb and G. Shoham}, journal={Biochemistry}, year={1983}, volume={22 5}, pages={1264-71} }