Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration.

  title={Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration.},
  author={Takashi Ashino and Varadarajan Sudhahar and Norifumi Urao and Jin Oshikawa and Gin-Fu Chen and Huan Wang and Yuqing Huo and Lydia A Finney and Stefan Vogt and Ronald D. McKinney and Edward B. Maryon and Jack H Kaplan and Masuko Ushio-Fukai and Tohru Fukai},
  journal={Circulation research},
  volume={107 6},
RATIONALE Copper, an essential nutrient, has been implicated in vascular remodeling and atherosclerosis with unknown mechanism. Bioavailability of intracellular copper is regulated not only by the copper importer CTR1 (copper transporter 1) but also by the copper exporter ATP7A (Menkes ATPase), whose function is achieved through copper-dependent translocation from trans-Golgi network (TGN). Platelet-derived growth factor (PDGF) promotes vascular smooth muscle cell (VSMC) migration, a key… CONTINUE READING


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Phosphorylation regulates copper-responsive trafficking of the Menkes 798 Circulation

NA Veldhuis, VA Valova, +9 authors J. Camakaris
Research September • 2010

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