Unexpected role of ceruloplasmin in intestinal iron absorption.

  title={Unexpected role of ceruloplasmin in intestinal iron absorption.},
  author={Srujana Cherukuri and Ramesh Potla and Joydeep Sarkar and Saul Nurko and Zena Leah Harris and Paul L. Fox},
  journal={Cell metabolism},
  volume={2 5},
Ferroxidases are essential for normal iron homeostasis in most organisms. The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. To clarify the function of Cp, we acutely bled Cp-/- mice to stress iron homeostasis pathways. Red cell hemoglobin recovery was defective in stressed Cp… CONTINUE READING


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