Unexpected role of ceruloplasmin in intestinal iron absorption.

@article{Cherukuri2005UnexpectedRO,
  title={Unexpected role of ceruloplasmin in intestinal iron absorption.},
  author={Srujana Cherukuri and Ramesh Potla and Joydeep Sarkar and Saul Nurko and Zena Leah Harris and Paul L. Fox},
  journal={Cell metabolism},
  year={2005},
  volume={2 5},
  pages={309-19}
}
Ferroxidases are essential for normal iron homeostasis in most organisms. The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen. To clarify the function of Cp, we acutely bled Cp-/- mice to stress iron homeostasis pathways. Red cell hemoglobin recovery was defective in stressed Cp… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 44 extracted citations

Similar Papers

Loading similar papers…