Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis.

@article{Han2017UnexpectedRF,
  title={Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis.},
  author={Xu Han and Jieying Zhang and Yuanliang Peng and Minyuan Peng and Xiao Chen and Huiyong Chen and Jianhui Song and Xiao Hu and Mao Ye and Jianglin Li and Vijay G Sankaran and Christopher D. Hillyer and Narla Mohandas and Xiuli An and Jing Liu},
  journal={Blood},
  year={2017},
  volume={129 2},
  pages={
          226-237
        }
}
Terminal erythroid differentiation is tightly coordinated with cell-cycle exit, which is regulated by cyclins, cyclin-dependent kinases, and cyclin-dependent kinase inhibitors (CDKI), yet their roles in erythropoiesis remain to be fully defined. We show here that p19INK4d, a member of CDKI family, is abundantly expressed in erythroblasts and that p19INK4d knockdown delayed erythroid differentiation, inhibited cell growth, and led to increased apoptosis and generation of abnormally nucleated… CONTINUE READING

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Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
Terminal erythroid differentiation is tightly coordinated with cell - cycle exit , which is regulated by cyclins , cyclin - dependent kinases , and cyclin - dependent kinase inhibitors ( CDKI ) , yet their roles in erythropoiesis remain to be fully defined .
GATA1 protein, humanGene product plays role in biological processErythropoiesis
Unexpected role for p19INK4d in posttranscriptional regulation of GATA1 and modulation of human terminal erythropoiesis .
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