Unexpected red cell antibodies in thalassemic children.


Nineteen of the 632 (3%) children with homozygous beta-thal and beta thal/Hb E developed alloantibodies to red cell antigens, primarily as a result of repeated transfusion. There were eight cases of anti-E, four cases of anti-E+, and two cases of anti-Le(a + b) antibodies. The low incidence rate in these patients is probably due to acquired tolerance. 


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