• Medicine
  • Published in
    The Netherlands journal of…
    2003

Unexpected prolonged extreme hypocalcaemia and an inadequate PTH response in a patient with metastatic breast carcinoma.

@article{Bergkamp2003UnexpectedPE,
  title={Unexpected prolonged extreme hypocalcaemia and an inadequate PTH response in a patient with metastatic breast carcinoma.},
  author={Ferry J.M. Bergkamp and Anne-Marie van Berkel and P W G van der Linden and J P Gorgels},
  journal={The Netherlands journal of medicine},
  year={2003},
  volume={61 11},
  pages={
          371-5
        }
}
Although hypercalcaemia is often encountered during the course of malignant disease, hypocalcaemia appears to be rather rare. We describe a 37-year-old patient with metastatic carcinoma of the breast, who developed extreme hypocalcaemia (as low as 0.75 mmol calcium per litre) after chemotherapy. This is caused by a combination of hungry-bone syndrome and an insufficient parathyroid response. The latter may be the result of a direct toxic effect of chemotherapy on parathyroid hormone (PTH… CONTINUE READING

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