Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis.

@article{Grabner2016UnexpectedOR,
  title={Unexpected oncosuppressive role for STAT3 in KRAS-induced lung tumorigenesis.},
  author={Beatrice Grabner and Herwig P Moll and Emilio Casanova},
  journal={Molecular & cellular oncology},
  year={2016},
  volume={3 3},
  pages={
          e1036199
        }
}
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in the pathogenesis of several diseases and is considered a therapeutic target in solid cancers, including lung cancer. However, we recently demonstrated a tumor suppressive function of STAT3 in kirsten rat sarcoma oncogene homolog (KRAS)-driven lung cancer. Here, we discuss these findings and their consequences. 
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