Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions.


8-Oxopurines (8-oxodG and 8-oxodA) and formamidopyrimidines (FaPydG and FaPydA) are major oxidative DNA lesions involved in cancer development and aging. Their mutagenicity is believed to result from a conformational shift of the N9-C1' glycosidic bonds from anti to syn, which allows the lesions to form noncanonical Hoogsteen-type base pairs with incoming… (More)
DOI: 10.1038/nchembio.1254


Cite this paper

@article{Gehrke2013UnexpectedNM, title={Unexpected non-Hoogsteen-based mutagenicity mechanism of FaPy-DNA lesions.}, author={Tim Gehrke and Ulrike Lischke and Karola L Gasteiger and Sabine Schneider and Simone Arnold and Heiko Mueller and David S Stephenson and Hendrik Zipse and Thomas Carell}, journal={Nature chemical biology}, year={2013}, volume={9 7}, pages={455-61} }