Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer.

@article{Shin2013UnexpectedGO,
  title={Unexpected gain of function for the scaffolding protein plectin due to mislocalization in pancreatic cancer.},
  author={Soo Jung Shin and Jeffrey A. Smith and G{\"u}nther A Rezniczek and Sheng Pan and Ru Chen and Teresa A. Brentnall and Gerhard Wiche and Kimberly A Kelly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 48},
  pages={19414-9}
}
We recently demonstrated that plectin is a robust biomarker for pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive malignancies. In normal physiology, plectin is an intracellular scaffolding protein, but we have demonstrated localization on the extracellular surface of PDAC cells. In this study, we confirmed cell surface localization… CONTINUE READING