Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich's ataxia.

@article{Leproust2000UnexpectedFO,
  title={Unexpected formation of parallel duplex in GAA and TTC trinucleotide repeats of Friedreich's ataxia.},
  author={Eric Leproust and Christopher E. Pearson and Richard R. Sinden and Xinfa Gao},
  journal={Journal of molecular biology},
  year={2000},
  volume={302 5},
  pages={1063-80}
}
The onset and progress of Friedreich's ataxia (FRDA) is associated with the genetic instability of the (GAA).(TTC) trinucleotide repeats located within the frataxin gene. The instability of these repeats may involve the formation of an alternative DNA structure. Poly-purine (R)/poly-pyrimidine (Y) sequences typically form triplex DNA structures which may… CONTINUE READING