Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.

@article{Zhou2001UnexpectedEO,
  title={Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.},
  author={Yong-xing Zhou and Maxine Chen and Nancy A. Cusack and Lida H. Kimmel and Kelly S. Magnuson and James Gorham Boyd and W Lin and Jaclyn L. Roberts and Andrea J. Lengi and Rebecca H Buckley and Robert L. Geahlen and Fabio Candotti and Massimo Gadina and Paul S. Changelian and John J O'Shea},
  journal={Molecular cell},
  year={2001},
  volume={8 5},
  pages={
          959-69
        }
}
Janus kinases comprise carboxyterminal kinase, pseudokinase, SH2-like, and N-terminal FERM domains. We identified three patient-derived mutations in the FERM domain of Jak3 and investigated the functional consequences of these mutations. These mutations inhibited receptor binding and also abrogated kinase activity, suggesting interactions between the FERM and kinase domains. In fact, the domains were found to physically associate, and coexpression of the FERM domain enhanced activity of the… CONTINUE READING

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