Unexpected domino reaction via Pd-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and cyclization to synthesize quinoline derivatives.

@article{Gao2010UnexpectedDR,
  title={Unexpected domino reaction via Pd-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and cyclization to synthesize quinoline derivatives.},
  author={Guo-lin Gao and Yan-ning Niu and Ze-Yi Yan and H Wang and Gang-Wei Wang and Ali Shaukat and Yong-Min Liang},
  journal={The Journal of organic chemistry},
  year={2010},
  volume={75 4},
  pages={1305-8}
}
A domino reaction via palladium-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and then cyclization to form quinoline derivatives has been developed. The reaction conditions and the scope of the process are examined, and a plausible mechanism is proposed. The procedure is simple, rapid, and general, and the substrates are readily available. 

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