Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast.

@article{Adams1993UnexpectedCO,
  title={Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast.},
  author={Alan E. Adams and John A. Cooper and David G Drubin},
  journal={Molecular biology of the cell},
  year={1993},
  volume={4 5},
  pages={459-68}
}
To understand the role of the actin cytoskeleton in cell physiology, and how actin-binding proteins regulate the actin cytoskeleton in vivo, we and others previously identified actin-binding proteins in Saccharomyces cerevisiae and studied the effect of null mutations in the genes for these proteins. A null mutation of the actin gene (ACT1) is lethal, but null mutations in the tropomyosin (TPM1), fimbrin (SAC6), Abp1p (ABP1), and capping protein (CAP1 and CAP2) genes have relatively mild or no… CONTINUE READING

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