Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain

@article{Dolique2013UnexpectedAO,
  title={Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain},
  author={Tiphaine Dolique and Alexandre Favereaux and Olivier Roca-Lapirot and Virginie Roques and Fr{\'e}d{\'e}ric Nagy},
  journal={PAIN®},
  year={2013},
  volume={154},
  pages={2529-2546}
}
In the spinal nerve ligation (SNL) model of neuropathic pain, synaptic plasticity shifts the excitation/inhibition balance toward excitation in the spinal dorsal horn. We investigated the deregulation of the synaptogenic neuroligin (NL) molecules, whose NL1 and NL2 isoforms are primarily encountered at excitatory and inhibitory synapses, respectively. In the dorsal horn of SNL rats, NL2 was overexpressed whereas NL1 remained unchanged. In control animals, intrathecal injections of small… CONTINUE READING

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