Unexpected and persistent depletion of B lymphocytes CD20 following a minimum dose of anti-CD20 antibody (Rituximab).

@article{Bruzzese2009UnexpectedAP,
  title={Unexpected and persistent depletion of B lymphocytes CD20 following a minimum dose of anti-CD20 antibody (Rituximab).},
  author={Vincenzo Bruzzese and Jessica Pepe},
  journal={Reumatismo},
  year={2009},
  volume={61 4},
  pages={306-8}
}
This study describes a woman patient suffering from rheumatoid arthritis which was resistant to treatment with the most commonly used DMARDs and anti-TNF alfa drugs, however following the administration of a minimum dose of Rituximab the patient showed a persistent and complete depletion of CD 20 lymphocytes. The dose of Rituximab administered to the… CONTINUE READING