Unexpected abundance of pathological tau in progressive supranuclear palsy white matter.

  title={Unexpected abundance of pathological tau in progressive supranuclear palsy white matter.},
  author={Victoria Zhukareva and Sonali Joyce and Teresa Schuck and Vivianna M Van Deerlin and Howard H. Hurtig and Roger Albin and Sid Gilman and Steven Chin and Bruce M Miller and John Q. Trojanowski and Virginia M-Y Lee},
  journal={Annals of neurology},
  volume={60 3},
OBJECTIVE To investigate whether biochemical insoluble tau with 4 (4R) and/or 3 (3R) microtubule-binding repeats accumulate in white as well as gray matter in progressive supranuclear palsy (PSP), a neurodegenerative tauopathy. METHODS To assess tau pathology in PSP white matter, we combined Western blot (WB) and immunohistochemical methods to analyze 23 autopsy-confirmed PSP brains. RESULTS WBs showed an unexpected abundance of insoluble tau in white and gray matter of PSP brains, but… CONTINUE READING


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