Unexpected Renal Actions of Erythropoietin

  title={Unexpected Renal Actions of Erythropoietin},
  author={Christof Westenfelder},
  journal={Nephron Experimental Nephrology},
  pages={294 - 298}
  • C. Westenfelder
  • Published 9 October 2002
  • Biology, Medicine
  • Nephron Experimental Nephrology
Erythropoietin (EPO) in the renal cortex is synthesized by fibroblast-like cells that are in direct contact with capillaries and adjacent tubular cells. Prompted by this anatomical relationship, we asked whether renal cells express EPO receptors (EPORs) through which EPO could act as a renotropic cytokine. We found that all regions of human, rat and mouse kidney, mesangial and proximal and distal tubular cells express authentic EPORs. Similar EPOR expression was detected in kidney cancer cells… 

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