Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom.

Abstract

After more than 70 years since its discovery, CF3CHN2 was found to possess a novel reactivity mode: N-terminal electrophile. With C-nucleophiles it gives hydrazones that are easily transformed into valuable CF3-heterocycles.

DOI: 10.1021/acs.orglett.6b01565

Cite this paper

@article{Arkhipov2016UnexpectedRO, title={Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N-Atom.}, author={Anton V Arkhipov and V. V. Arkhipov and Janine Cossy and Volodymir O Kovtunenko and Pavel K Mykhailiuk}, journal={Organic letters}, year={2016}, volume={18 14}, pages={3406-9} }